Guía Docente 2023-24
QUÍMICA FARMACÉUTICA II

BASIC DETAILS:

Subject: QUÍMICA FARMACÉUTICA II
Id.: 33608
Programme: GRADUADO EN FARMACIA. PLAN 2019
Module: QUÍMICA
Subject type: OBLIGATORIA
Year: 3 Teaching period: Primer Cuatrimestre
Credits: 6 Total hours: 150
Classroom activities: 72 Individual study: 78
Main teaching language: Castellano Secondary teaching language: Inglés
Lecturer: Email:

PRESENTATION:

Pharmaceutical Chemistry II may be one of the most multidisciplinary subjects in the Pharmacy Degree because it encompasses contents from other previous subjects, such as Biology, Mathematics, Organic and Inorganic chemistry, among others, and it is an essential subject in the education of any pharmacist. This subject is under Chemistry in the Pharmacy Curriculum. 

The main goal of Pharmaceutical Chemistry II is to study drugs -from a chemical point of view- and the basic principles to create effective and safe drugs. To achieve this purpose, knowing the relationship between the structure of chemical compounds and their activity is required for each drug.

 

 

PROFESSIONAL COMPETENCES ACQUIRED IN THE SUBJECT:

Specific programme competences E01 Identificar, diseñar, obtener, analizar y producir principios activos, fármacos y otros productos y materiales de interés sanitario.
E04 Estimar los riesgos asociados a la utilización de sustancias químicas y procesos de laboratorio.
E05 Conocer las características físico-químicas de las sustancias utilizadas para la fabricación de los medicamentos.
E08 Conocer y comprender la naturaleza y comportamientos de los grupos funcionales en moléculas orgánicas.
E09 Conocer el origen, naturaleza, diseño, obtención análisis y control de medicamentos y productos sanitarios.
E25 Conocer las principales rutas metabólicas que intervienen en la degradación de fármacos.
E46 Conocer las propiedades y mecanismos de acción de los fármacos.
Regulated profession competences P01 Identificar, diseñar, obtener, analizar, controlar y producir fármacos y medicamentos, así como otros productos y materias primas de interés sanitario de uso humano o veterinario.
P15 Recognise the limitations and the need to maintain and update professional skills, with particular emphasis on self-learning of new knowledge based on the available scientific evidence.
Learning outcomes R01 Nombrar y formular fármacos sencillos.
R02 Argumentar el tipo de interacción fármaco-receptor a partir de la estructura de ambos.
R03 Explicar el mecanismo de reacción de los fármacos quimioterápicos y farmacodinámicos más representativos.
R04 Predecir la secuencia de reacciones metabólicas de Fase I y II dado un fármaco.
R05 Explicar las reacciones de bioactivación de profármacos.
R06 Analizar la relación cualitativa y cuantitativa entre la estructura de un fármaco y su actividad biológica.
R07 Explicar los procesos de optimización de un prototipo.

PRE-REQUISITES:

Students should have previous knowledge of biology, mathematics, general chemistry and organic chemistry.

 

 

SUBJECT PROGRAMME:

Subject contents:

1 - BASIC CONCEPTS
    1.1 - What is Pharmaceutical Chemistry?
    1.2 - Steps in Pharmaceutical Chemistry
    1.3 - Key words and definitions
2 - DRUG CLASSIFICATION
    2.1 - Different types of drug classification
3 - NOMENCLATURE
    3.1 - Introduction
    3.2 - Code names
    3.3 - Trade names
    3.4 - Common denominations
    3.5 - Chemical names: systematic and semisystematic
4 - RECEPTORS AND INTERACTIONS
    4.1 - Biological receptors and ligands
    4.2 - Drug-receptor interactions
5 - DRUG METABOLISM
    5.1 - Introduction
    5.2 - Phase I reactions
    5.3 - Phase II reactions
6 - PRODRUGS
    6.1 - Introduction
    6.2 - Types of prodrugs
    6.3 - Activation mechanism of prodrugs
7 - OPTIMIZATION OF A PROTOTYPE I
    7.1 - Introduction
    7.2 - Different types of molecular modification
    7.3 - Classical criteria for the systematic modification of structural entities
    7.4 - An example of application: modifications on the peptidic bond
8 - OPTIMIZATION OF A PROTOTYPE II: QSAR
    8.1 - Introduction
    8.2 - Solubility descriptors for drugs
9 - DRUGS ACTING ON ION CHANNELS AND OTHER MEMBRANE RECEPTORS
    9.1 - Introduction
    9.2 - Ionic channels
    9.3 - Other related receptors
10 - CHEMOTHERAPEUTIC DRUGS
    10.1 - Introduction
    10.2 - Mode of action of some chemotherapeutic drugs
11 - PHARMACODYNAMIC DRUGS
    11.1 - Introduction
    11.2 - Mode of action of some pharmacodynamics drugs

Subject planning could be modified due unforeseen circumstances (group performance, availability of resources, changes to academic calendar etc.) and should not, therefore, be considered to be definitive.


TEACHING AND LEARNING METHODOLOGIES AND ACTIVITIES:

Teaching and learning methodologies and activities applied:

This subject is based on active participation, for which different teaching and learning methodologies will be applied: Master classes (Lecturing), Flipped classroom approach, Collaborative work, Problem-based learning, Role playing and Gamification. A socio-constructivist approach will be used to teaching and learning and learner autonomy and responsibility is, therefore, essential to achieve the required tasks.

 

 

Student work load:

Teaching mode Teaching methods Estimated hours
Classroom activities
Master classes 26
Other theory activities 1
Practical exercises 10
Practical work, exercises, problem-solving etc. 10
Coursework presentations 1
Films, videos, documentaries etc. 1
Laboratory practice 16
Participation in seminars, conferences etc. 1
Assessment activities 6
Individual study
Tutorials 1
Individual study 58
Individual coursework preparation 2
Group cousework preparation 13
Research work 3
Compulsory reading 1
Total hours: 150

ASSESSMENT SCHEME:

Calculation of final mark:

Individual coursework: 15 %
Group coursework: 20 %
Final exam: 45 %
Laboratory work: 20 %
TOTAL 100 %

*Las observaciones específicas sobre el sistema de evaluación serán comunicadas por escrito a los alumnos al inicio de la materia.

BIBLIOGRAPHY AND DOCUMENTATION:

Basic bibliography:

Avendaño, C. Introducción a la Química Farmacéutica. 2º Edición. Ed. Interamericana -Mc Graw-Hill, 2001
J. A. Galbis. Panorama actual de la Química Farmacéutica. Ed. Universidad de Sevilla, 2000
Pharmaceutical chemistry: therapeutic aspects of biomacromolecules. Bladon, Christine M. Ed. John Wiley
The organic chemistry of drug design action. Second Edition. Richard B. Silverman. Ed. Elsevier

Recommended bibliography:

Gilchrist, T. L. 1995. Heterocyclic chemistry. Ed. Longman

Recommended websites:


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