Guía Docente 2023-24 QUÍMICA FARMACÉUTICA II |
BASIC DETAILS:
Subject: | QUÍMICA FARMACÉUTICA II | ||
Id.: | 33608 | ||
Programme: | GRADUADO EN FARMACIA. PLAN 2019 | ||
Module: | QUÍMICA | ||
Subject type: | OBLIGATORIA | ||
Year: | 3 | Teaching period: | Primer Cuatrimestre |
Credits: | 6 | Total hours: | 150 |
Classroom activities: | 72 | Individual study: | 78 |
Main teaching language: | Castellano | Secondary teaching language: | Inglés |
Lecturer: | Email: |
PRESENTATION:
Pharmaceutical Chemistry II may be one of the most multidisciplinary subjects in the Pharmacy Degree because it encompasses contents from other previous subjects, such as Biology, Mathematics, Organic and Inorganic chemistry, among others, and it is an essential subject in the education of any pharmacist. This subject is under Chemistry in the Pharmacy Curriculum.
The main goal of Pharmaceutical Chemistry II is to study drugs -from a chemical point of view- and the basic principles to create effective and safe drugs. To achieve this purpose, knowing the relationship between the structure of chemical compounds and their activity is required for each drug.
PROFESSIONAL COMPETENCES ACQUIRED IN THE SUBJECT:
Specific programme competences | E01 | Identificar, diseñar, obtener, analizar y producir principios activos, fármacos y otros productos y materiales de interés sanitario. |
E04 | Estimar los riesgos asociados a la utilización de sustancias químicas y procesos de laboratorio. | |
E05 | Conocer las características físico-químicas de las sustancias utilizadas para la fabricación de los medicamentos. | |
E08 | Conocer y comprender la naturaleza y comportamientos de los grupos funcionales en moléculas orgánicas. | |
E09 | Conocer el origen, naturaleza, diseño, obtención análisis y control de medicamentos y productos sanitarios. | |
E25 | Conocer las principales rutas metabólicas que intervienen en la degradación de fármacos. | |
E46 | Conocer las propiedades y mecanismos de acción de los fármacos. | |
Regulated profession competences | P01 | Identificar, diseñar, obtener, analizar, controlar y producir fármacos y medicamentos, así como otros productos y materias primas de interés sanitario de uso humano o veterinario. |
P15 | Recognise the limitations and the need to maintain and update professional skills, with particular emphasis on self-learning of new knowledge based on the available scientific evidence. | |
Learning outcomes | R01 | Nombrar y formular fármacos sencillos. |
R02 | Argumentar el tipo de interacción fármaco-receptor a partir de la estructura de ambos. | |
R03 | Explicar el mecanismo de reacción de los fármacos quimioterápicos y farmacodinámicos más representativos. | |
R04 | Predecir la secuencia de reacciones metabólicas de Fase I y II dado un fármaco. | |
R05 | Explicar las reacciones de bioactivación de profármacos. | |
R06 | Analizar la relación cualitativa y cuantitativa entre la estructura de un fármaco y su actividad biológica. | |
R07 | Explicar los procesos de optimización de un prototipo. |
PRE-REQUISITES:
Students should have previous knowledge of biology, mathematics, general chemistry and organic chemistry.
SUBJECT PROGRAMME:
Subject contents:
1 - BASIC CONCEPTS |
1.1 - What is Pharmaceutical Chemistry? |
1.2 - Steps in Pharmaceutical Chemistry |
1.3 - Key words and definitions |
2 - DRUG CLASSIFICATION |
2.1 - Different types of drug classification |
3 - NOMENCLATURE |
3.1 - Introduction |
3.2 - Code names |
3.3 - Trade names |
3.4 - Common denominations |
3.5 - Chemical names: systematic and semisystematic |
4 - RECEPTORS AND INTERACTIONS |
4.1 - Biological receptors and ligands |
4.2 - Drug-receptor interactions |
5 - DRUG METABOLISM |
5.1 - Introduction |
5.2 - Phase I reactions |
5.3 - Phase II reactions |
6 - PRODRUGS |
6.1 - Introduction |
6.2 - Types of prodrugs |
6.3 - Activation mechanism of prodrugs |
7 - OPTIMIZATION OF A PROTOTYPE I |
7.1 - Introduction |
7.2 - Different types of molecular modification |
7.3 - Classical criteria for the systematic modification of structural entities |
7.4 - An example of application: modifications on the peptidic bond |
8 - OPTIMIZATION OF A PROTOTYPE II: QSAR |
8.1 - Introduction |
8.2 - Solubility descriptors for drugs |
9 - DRUGS ACTING ON ION CHANNELS AND OTHER MEMBRANE RECEPTORS |
9.1 - Introduction |
9.2 - Ionic channels |
9.3 - Other related receptors |
10 - CHEMOTHERAPEUTIC DRUGS |
10.1 - Introduction |
10.2 - Mode of action of some chemotherapeutic drugs |
11 - PHARMACODYNAMIC DRUGS |
11.1 - Introduction |
11.2 - Mode of action of some pharmacodynamics drugs |
Subject planning could be modified due unforeseen circumstances (group performance, availability of resources, changes to academic calendar etc.) and should not, therefore, be considered to be definitive.
TEACHING AND LEARNING METHODOLOGIES AND ACTIVITIES:
Teaching and learning methodologies and activities applied:
This subject is based on active participation, for which different teaching and learning methodologies will be applied: Master classes (Lecturing), Flipped classroom approach, Collaborative work, Problem-based learning, Role playing and Gamification. A socio-constructivist approach will be used to teaching and learning and learner autonomy and responsibility is, therefore, essential to achieve the required tasks.
Student work load:
Teaching mode | Teaching methods | Estimated hours |
Classroom activities | ||
Master classes | 26 | |
Other theory activities | 1 | |
Practical exercises | 10 | |
Practical work, exercises, problem-solving etc. | 10 | |
Coursework presentations | 1 | |
Films, videos, documentaries etc. | 1 | |
Laboratory practice | 16 | |
Participation in seminars, conferences etc. | 1 | |
Assessment activities | 6 | |
Individual study | ||
Tutorials | 1 | |
Individual study | 58 | |
Individual coursework preparation | 2 | |
Group cousework preparation | 13 | |
Research work | 3 | |
Compulsory reading | 1 | |
Total hours: | 150 |
ASSESSMENT SCHEME:
Calculation of final mark:
Individual coursework: | 15 | % |
Group coursework: | 20 | % |
Final exam: | 45 | % |
Laboratory work: | 20 | % |
TOTAL | 100 | % |
*Las observaciones específicas sobre el sistema de evaluación serán comunicadas por escrito a los alumnos al inicio de la materia.
BIBLIOGRAPHY AND DOCUMENTATION:
Basic bibliography:
Avendaño, C. Introducción a la Química Farmacéutica. 2º Edición. Ed. Interamericana -Mc Graw-Hill, 2001 |
J. A. Galbis. Panorama actual de la Química Farmacéutica. Ed. Universidad de Sevilla, 2000 |
Pharmaceutical chemistry: therapeutic aspects of biomacromolecules. Bladon, Christine M. Ed. John Wiley |
The organic chemistry of drug design action. Second Edition. Richard B. Silverman. Ed. Elsevier |
Recommended bibliography:
Gilchrist, T. L. 1995. Heterocyclic chemistry. Ed. Longman |
Recommended websites:
* Guía Docente sujeta a modificaciones