![]() | Guía Docente 2024-25 QUÍMICA FARMACÉUTICA |
BASIC DETAILS:
Subject: | QUÍMICA FARMACÉUTICA | ||
Id.: | 33292 | ||
Programme: | GRADUADO EN BIOINFORMÁTICA. PLAN 2019 (BOE 06/02/2019) | ||
Module: | QUÍMICA | ||
Subject type: | OBLIGATORIA | ||
Year: | 2 | Teaching period: | Segundo Cuatrimestre |
Credits: | 6 | Total hours: | 150 |
Classroom activities: | 66 | Individual study: | 84 |
Main teaching language: | Inglés | Secondary teaching language: | Castellano |
Lecturer: | Email: |
PRESENTATION:
Pharmaceutical chemistry is a subject where biology and chemistry come together.
The main goal of Pharmaceutical Chemistry is to study drugs -from a chemical point of view- and the basic principles to create effective and safe drugs. To achieve this purpose, knowing the relationship between the structure of chemical compounds and their activity is required for each drug.
PROFESSIONAL COMPETENCES ACQUIRED IN THE SUBJECT:
General programme competences | G05 | Communicate professional topics in Spanish and / or English both orally and in writing. |
G07 | Choose between different complex models of knowledge to solve problems. | |
G08 | Recognise the role of the scientific method in the generation of knowledge and its applicability to a professional environment. | |
G10 | Apply creativity, independence of thought, self-criticism and autonomy in the professional practice. | |
Specific programme competences | E19 | Explain the main biochemical reactions by applying the principles of chemical kinetics and thermodynamics. |
E21 | Apply computational and data processing techniques for the integration of physical, chemical and biological concepts and data for the description and/ or prediction of the activity of a substance in a given context. | |
Learning outcomes | R01 | Differentiate between drug, medication, bioactive compound, receptor and therapeutic target. |
R02 | Describe the main types of interaction between ligand and receptor. | |
R03 | Define the main parameters that characterize the ligand-receptor interaction. | |
R04 | Infer the nature of the drug-receptor complex from the type of interaction between both. | |
R05 | Interpret dose-response curves. | |
R06 | Represent small molecules using computer tools. | |
R07 | Explain the relationship between molecular structure and the main parameters of bioactivity. | |
R08 | Explain the main approaches in the optimisation of drug prototypes. |
PRE-REQUISITES:
Students are strongly recommended to have past General chemistry, Fundamentals of biology and Fundamentals of biochesmitry and molecular biology.
SUBJECT PROGRAMME:
Subject contents:
1 - FUNDAMENTALS OF MOLECULES |
1.1 - Bonds and molecular geometry |
1.2 - Molecular interactions |
1.3 - Conformers |
2 - FUNDAMENTALS OF REACTIONS |
2.1 - Kinetic and thermodynamic viability of a reaction |
2.2 - Catalysts |
2.3 - Metabolic reactions. Drug metabolism |
3 - BASIC CONCEPTS AND DEFINITIOS OF PHARMACEUTICAL CHEMISTRY |
3.1 - Drug. Pharmacophore. Medicine. Excipients. |
3.2 - Target |
4 - DRUG-RECEPTOR INTERACTIONS. TYPES AND CHARACTERISTICS. |
4.1 - Reversible/irreversible |
4.2 - Competitive/non-competitive |
4.3 - Dose-response curve |
5 - PROTOTYPE OPTIMIZATION |
5.1 - Homology |
5.2 - Vinylogy |
5.3 - Bioisosterism |
6 - SAR |
7 - QSAR |
Subject planning could be modified due unforeseen circumstances (group performance, availability of resources, changes to academic calendar etc.) and should not, therefore, be considered to be definitive.
TEACHING AND LEARNING METHODOLOGIES AND ACTIVITIES:
Teaching and learning methodologies and activities applied:
This subject is based on active participation, for which different teaching and learning methodologies will be applied: Master classes (Lecturing), Flipped classroom approach, Problem-based learning. A socio-constructivist approach will be used to teaching and learning and learner autonomy and responsibility is, therefore, essential to achieve the required tasks.
Student work load:
Teaching mode | Teaching methods | Estimated hours |
Classroom activities | ||
Master classes | 22 | |
Other theory activities | 8 | |
Practical work, exercises, problem-solving etc. | 16 | |
Laboratory practice | 4 | |
Other practical activities | 12 | |
Assessment activities | 4 | |
Individual study | ||
Tutorials | 2 | |
Individual study | 32 | |
Individual coursework preparation | 26 | |
Research work | 12 | |
Compulsory reading | 12 | |
Total hours: | 150 |
ASSESSMENT SCHEME:
Calculation of final mark:
Tests: | 15 | % |
Exámenes escritos: | 50 | % |
Evaluación de trabajos/ensayos: | 20 | % |
Evaluación de ejecuciones con criterios explícitos y públicos del trabajo de laboratorio: | 15 | % |
TOTAL | 100 | % |
*Las observaciones específicas sobre el sistema de evaluación serán comunicadas por escrito a los alumnos al inicio de la materia.
BIBLIOGRAPHY AND DOCUMENTATION:
Basic bibliography:
Avendaño, C. Introducción a la Química Farmacéutica. Ed. Interamericana -Mc Graw-Hill |
Housecroft, C. e. y Sharpe A. G. Química Inorgánica. Madrid:Pearson Alhambra |
Pharmaceutical chemistry: therapeutic aspects of biomacromolecules. Bladon, Christine M. Ed. John Wiley |
Química General. Petrucci R. H. y Harwood, W. S. Quiñoá Cabana, E. |
Recommended bibliography:
Recommended websites:
Khan Academy | https://es.khanacademy.org/ |
* Guía Docente sujeta a modificaciones