Guía Docente 2020-21
QUÍMICA FARMACÉUTICA

BASIC DETAILS:

Subject: QUÍMICA FARMACÉUTICA
Id.: 33292
Programme: GRADUADO EN BIOINFORMÁTICA. PLAN 2019 (BOE 06/02/2019)
Module: QUÍMICA
Subject type: OBLIGATORIA
Year: 2 Teaching period: Segundo Cuatrimestre
Credits: 6 Total hours: 150
Classroom activities: 66 Individual study: 84
Main teaching language: Inglés Secondary teaching language: Castellano
Lecturer: Email:

PRESENTATION:

Pharmaceutical chemistry is a subject where biology and chemistry come together.

The main goal of Pharmaceutical Chemistry is to study drugs -from a chemical point of view- and the basic principles to create effective and safe drugs. To achieve this purpose, knowing the relationship between the structure of chemical compounds and their activity is required for each drug.

 

 

 

 

PROFESSIONAL COMPETENCES ACQUIRED IN THE SUBJECT:

General programme competences G05 Communicate professional topics in Spanish and / or English both orally and in writing.
G07 Choose between different complex models of knowledge to solve problems.
G08 Recognise the role of the scientific method in the generation of knowledge and its applicability to a professional environment.
G10 Apply creativity, independence of thought, self-criticism and autonomy in the professional practice.
Specific programme competences E19 Explain the main biochemical reactions by applying the principles of chemical kinetics and thermodynamics.
E21 Apply computational and data processing techniques for the integration of physical, chemical and biological concepts and data for the description and/ or prediction of the activity of a substance in a given context.
Learning outcomes R01 Differentiate between drug, medication, bioactive compound, receptor and therapeutic target.
R02 Describe the main types of interaction between ligand and receptor.
R03 Define the main parameters that characterize the ligand-receptor interaction.
R04 Infer the nature of the drug-receptor complex from the type of interaction between both.
R05 Interpret dose-response curves.
R06 Represent small molecules using computer tools.
R07 Explain the relationship between molecular structure and the main parameters of bioactivity.
R08 Explain the main approaches in the optimisation of drug prototypes.

PRE-REQUISITES:

Students are strongly recommended to have past General chemistry, Fundamentals of biology and Fundamentals of biochesmitry and molecular biology.

SUBJECT PROGRAMME:

Subject contents:

1 - FUNDAMENTALS OF MOLECULES
    1.1 - Bonds and molecular geometry
    1.2 - Molecular interactions
    1.3 - Conformers
2 - FUNDAMENTALS OF REACTIONS
    2.1 - Kinetic and thermodynamic viability of a reaction
    2.2 - Catalysts
    2.3 - Metabolic reactions. Drug metabolism
3 - BASIC CONCEPTS AND DEFINITIOS OF PHARMACEUTICAL CHEMISTRY
    3.1 - Drug. Pharmacophore. Medicine. Excipients.
    3.2 - Target
4 - DRUG-RECEPTOR INTERACTIONS. TYPES AND CHARACTERISTICS.
    4.1 - Reversible/irreversible
    4.2 - Competitive/non-competitive
    4.3 - Dose-response curve
5 - PROTOTYPE OPTIMIZATION
    5.1 - Homology
    5.2 - Vinylogy
    5.3 - Bioisosterism
6 - SAR
7 - QSAR

Subject planning could be modified due unforeseen circumstances (group performance, availability of resources, changes to academic calendar etc.) and should not, therefore, be considered to be definitive.


TEACHING AND LEARNING METHODOLOGIES AND ACTIVITIES:

Teaching and learning methodologies and activities applied:

This subject is based on active participation, for which different teaching and learning methodologies will be applied: Master classes (Lecturing), Flipped classroom approach, Problem-based learning. A socio-constructivist approach will be used to teaching and learning and learner autonomy and responsibility is, therefore, essential to achieve the required tasks.

Student work load:

Teaching mode Teaching methods Estimated hours
Classroom activities
Master classes 22
Other theory activities 8
Practical work, exercises, problem-solving etc. 16
Laboratory practice 4
Other practical activities 12
Assessment activities 4
Individual study
Tutorials 2
Individual study 32
Individual coursework preparation 26
Research work 12
Compulsory reading 12
Total hours: 150

ASSESSMENT SCHEME:

Calculation of final mark:

Tests: 15 %
Exámenes escritos: 50 %
Evaluación de trabajos/ensayos: 20 %
Evaluación de ejecuciones con criterios explícitos y públicos del trabajo de laboratorio: 15 %
TOTAL 100 %

*Las observaciones específicas sobre el sistema de evaluación serán comunicadas por escrito a los alumnos al inicio de la materia.

BIBLIOGRAPHY AND DOCUMENTATION:

Basic bibliography:

Housecroft, C. e. y Sharpe A. G. Química Inorgánica. Madrid:Pearson Alhambra
Química General. Petrucci R. H. y Harwood, W. S. Quiñoá Cabana, E.
Avendaño, C. Introducción a la Química Farmacéutica. Ed. Interamericana -Mc Graw-Hill
Pharmaceutical chemistry: therapeutic aspects of biomacromolecules. Bladon, Christine M. Ed. John Wiley

Recommended bibliography:

Recommended websites:

Khan Academy https://es.khanacademy.org/


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