Guía Docente 2020-21
QUÍMICA FARMACÉUTICA II

BASIC DETAILS:

Subject: QUÍMICA FARMACÉUTICA II
Id.: 31653
Programme: GRADUADO EN FARMACIA. PLAN 2013 (BOE 15/07/2013)
Module: QUÍMICA
Subject type: OBLIGATORIA
Year: 3 Teaching period: Primer Cuatrimestre
Credits: 6 Total hours: 150
Classroom activities: 82 Individual study: 68
Main teaching language: Castellano Secondary teaching language: Inglés
Lecturer: Email:

PRESENTATION:

Pharmaceutical Chemistry II may be one of the most multidisciplinary subjects in the Pharmacy Degree because it encompasses contents from other previous subjects, such as Biology, Mathematics, Organic and Inorganic chemistry, among others, and it is an essential subject in the education of any pharmacist. This subject is under Chemistry in the Pharmacy Curriculum. 

The main goal of Pharmaceutical Chemistry II is to study drugs -from a chemical point of view- and the basic principles to create effective and safe drugs. To achieve this purpose, knowing the relationship between the structure of chemical compounds and their activity is required for each drug.

 

 

PROFESSIONAL COMPETENCES ACQUIRED IN THE SUBJECT:

General programme competences G01 Ability to express opinions and propose arguments effectively both orally and in writing. Effectively use language skills to express views and formulate arguments both orally and in writing.
G02 Troubleshooting and decision-making.
G03 Ability for autonomous learning and self-criticism.
G05 Ability for teamwork, actively contributing to the objectives and the organisation of a team.
Specific programme competences E01 Identify, design, collect, analyse and produce active ingredients, drugs and other products and materials related to the health sector.
E02 Select the appropriate techniques and procedures in the design, implementation and evaluation of reagents and analytical techniques and methods.
E11 Know about and apply the main techniques of structural investigation including spectroscopy.
Regulated profession competences P01 Identify, design, collect, analyse, control and produce drugs and medication and other healthcare products for human and veterinary use.
Learning outcomes R01 Know and understand the synthesis pathways of the main groups of drugs.
R02 Know and understand the chemical characteristics of the main chemotherapy drugs and their mechanism of action.
R03 Know and understand the chemical characteristics of the main pharmacodynamic drugs and their mechanism of action.
R04 Know and understand the chemical characteristics of the main drugs that alter the transport through membranes and their mechanism of action.
R05 Know and understand the new extraction methods of active plant principles.

PRE-REQUISITES:

Students should have previous knowledge of biology, mathematics, general chemistry and organic chemistry.

 

 

SUBJECT PROGRAMME:

Subject contents:

1 - BASIC CONCEPTS
    1.1 - What is Pharmaceutical Chemistry?
    1.2 - Steps in Pharmaceutical Chemistry
    1.3 - Key words and definitions
2 - DRUG CLASSIFICATION
    2.1 - Different types of drug classification
3 - NOMENCLATURE
    3.1 - Introduction
    3.2 - Code names
    3.3 - Trade names
    3.4 - Common denominations
    3.5 - Chemical names: systematic and semisystematic
4 - RECEPTORS AND INTERACTIONS
    4.1 - Biological receptors and ligands
    4.2 - Drug-receptor interactions
5 - DRUG METABOLISM
    5.1 - Introduction
    5.2 - Phase I reactions
    5.3 - Phase II reactions
6 - PRODRUGS
    6.1 - Introduction
    6.2 - Types of prodrugs
    6.3 - Activation mechanism of prodrugs
7 - OPTIMIZATION OF A PROTOTYPE I
    7.1 - Introduction
    7.2 - Different types of molecular modification
    7.3 - Classical criteria for the systematic modification of structural entities
    7.4 - An example of application: modifications on the peptidic bond
8 - OPTIMIZATION OF A PROTOTYPE II: QSAR
    8.1 - Introduction
    8.2 - Solubility descriptors for drugs
9 - DRUGS ACTING ON ION CHANNELS AND OTHER MEMBRANE RECEPTORS
    9.1 - Introduction
    9.2 - Ionic channels
    9.3 - Other related receptors
10 - CHEMOTHERAPEUTIC DRUGS
    10.1 - Introduction
    10.2 - Mode of action of some chemotherapeutic drugs
11 - PHARMACODYNAMIC DRUGS
    11.1 - Introduction
    11.2 - Mode of action of some pharmacodynamics drugs

Subject planning could be modified due unforeseen circumstances (group performance, availability of resources, changes to academic calendar etc.) and should not, therefore, be considered to be definitive.


TEACHING AND LEARNING METHODOLOGIES AND ACTIVITIES:

Teaching and learning methodologies and activities applied:

This subject is based on active participation, for which different teaching and learning methodologies will be applied: Master classes (Lecturing), Flipped classroom approach, Collaborative work, Problem-based learning, Role playing and Gamification. A socio-constructivist approach will be used to teaching and learning and learner autonomy and responsibility is, therefore, essential to achieve the required tasks.

 

 

Student work load:

Teaching mode Teaching methods Estimated hours
Classroom activities
Master classes 32
Other theory activities 1
Practical exercises 10
Practical work, exercises, problem-solving etc. 14
Coursework presentations 1
Films, videos, documentaries etc. 1
Laboratory practice 16
Participation in seminars, conferences etc. 1
Assessment activities 6
Individual study
Tutorials 1
Individual study 48
Individual coursework preparation 2
Group cousework preparation 13
Research work 3
Compulsory reading 1
Total hours: 150

ASSESSMENT SCHEME:

Calculation of final mark:

Individual coursework: 15 %
Group coursework: 20 %
Final exam: 45 %
Laboratory work: 20 %
TOTAL 100 %

*Las observaciones específicas sobre el sistema de evaluación serán comunicadas por escrito a los alumnos al inicio de la materia.

BIBLIOGRAPHY AND DOCUMENTATION:

Basic bibliography:

Avendaño, C. Introducción a la Química Farmacéutica. 2º Edición. Ed. Interamericana -Mc Graw-Hill, 2001
J. A. Galbis. Panorama actual de la Química Farmacéutica. Ed. Universidad de Sevilla, 2000
Pharmaceutical chemistry: therapeutic aspects of biomacromolecules. Bladon, Christine M. Ed. John Wiley
The organic chemistry of drug design action. Second Edition. Richard B. Silverman. Ed. Elsevier

Recommended bibliography:

Gilchrist, T. L. 1995. Heterocyclic chemistry. Ed. Longman

Recommended websites:


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